Scientists discover brain circuit that can switch off chronic pain

Scientists have pinpointed Y1 receptor neurons in the brain that can override chronic pain signals when survival instincts like hunger or fear take precedence. Acting like a neural switchboard, these cells balance pain with other biological needs. The research could pave the way for personalized treatments that target pain at its brain source—offering hope for millions living with long-term pain.

source https://www.sciencedaily.com/releases/2025/10/251009033126.htm