The longevity factor Foxo3 mediates 'unfit' cell elimination to ensure healthy body construction

Researchers have revealed some of the precise mechanisms by which erroneous cells are recognized, marked for removal, and eliminated via apoptosis in developing zebrafish. Notably, they found that the protein Foxo3 may be a universal marker of cell competition in zebrafish and mice. These findings have important implications for congenital disorders, cancer, and aging, and may lead to novel treatments.

source https://www.sciencedaily.com/releases/2024/12/241217131237.htm