The hidden DNA organizer linking fertility and cancer

Scientists at Kyoto University have uncovered a hidden protein complex that organizes DNA in sperm stem cells, a discovery that reveals surprising ties between fertility and cancer. When this protein, called STAG3, is missing, sperm stem cells cannot mature properly, leading to infertility in mice. Even more intriguing, the same protein is found in high levels in certain immune cells and cancers, and blocking it slowed tumor growth in the lab.

source https://www.sciencedaily.com/releases/2025/08/250826005229.htm