Cold sore virus hijacks human genome in 3D--and scientists found its weak spot

Cold sore-causing HSV-1 doesn't just hijack cells it reconfigures the entire architecture of our DNA to aid its invasion. Researchers discovered that it actively reshapes the 3D structure of the human genome within hours of infection, using host enzymes like topoisomerase I to gain access to crucial genetic machinery. Stunningly, blocking this single enzyme shuts the virus down completely.

source https://www.sciencedaily.com/releases/2025/06/250620031207.htm